Counter temporarily out of order due to NetScrape Server stupidity.

THE DEXTROMETHORPHAN FAQ




ANSWERS TO FREQUENTLY ASKED QUESTIONS

ABOUT DEXTROMETHORPHAN (DXM)



William E. White





Hardcopy Version 3.0

Copyright © 1995 All Rights Reserved

Originally Written for Usenet alt.drugs

New! Comments, questions, or feedback? Please take a moment to fill out this form.

--- --- --- --- --- --- --- --- --- --- --- ---

This document is a FAQ ("fack"), i.e., a series of questions and answers. The term comes from Usenet, and stands for Frequently Asked Questions. These are the sorts of questions that people new to Usenet tend to ask frequently. When these questions become frequent enough, the question and its answer may be placed into the FAQ for the newsgroup (or for a topic within the newsgroup). A few people use the term AFAQ (Answers to Frequently Asked Questions), but most use FAQ to refer both to a frequent question and to the document written to answer such questions.

This FAQ covers dextromethorphan (decks-tro-meth-OR-fan), the cough suppressant commonly found in cough medicines available over-the-counter in the USA and other parts of the world. Of course, dextromethorphan (DXM) does more than suppress coughs; otherwise, there wouldn't be so much discussion about it on alt.drugs (the Usenet newsgroup from which this FAQ originated). The bizarre truth about DXM is that it is a very potent psychoactive drug when taken in sufficient quantities. So if you've ever heard about people drinking cough syrup for fun, well, now you know why.

The trouble, however, is that most cough medicines have other ingredients which can make you uncomfortable, sick, or dead, depending on the ingredient and how much you take. This document is primarily intended to combat potentially dangerous misinformation about the recreational use of DXM.

My own interest in DXM came quite by accident; once, while sick with the flu, I misread the instructions on a bottle of cough syrup and drank two shots from the included shotglass instead of two teaspoons. Soon after I noticed that music and motion had become very satisfying experiences. This left me puzzled, and my reaction was to go to the library and research DXM through Medline, medical journals, and books.

Of course at that point I was hooked - not on DXM, but on neuropharmacology. I decided to learn as much as I could about DXM, and found it to be one of the most unique and interesting of all recreational drugs in terms of how it works on the brain.

About this time I noticed a number of incorrect and potentially dangerous posts (articles) about DXM appearing on alt.drugs. So, I decided to gather the information I had and write a FAQ. It eventually became much more than a FAQ, giving explanations and information in addition to answers, but by then the name had stuck. The FAQ took me over 150 hours to complete - I figured if I'm going to do it, I'd better do it right.

After publishing the DXM FAQ, the reports of DXM use started coming in. People who had been using DXM but were uncomfortable talking about "getting high off cough syrup" shared their stories with me. Some were good, some were bad, some indifferent. I've been trying my best to get all of these personal reports together into a coherent whole, but this FAQ is written in my free time and I don't get paid for it (although donations are acceptable :^).

Please note that it is not my intention to get a bunch of people hooked on cough syrup (actually addiction is very rare, but you get my point). It is my intention for people to know the truth so they don't make bad decisions for lack of knowledge. DXM is not safe and harmless; nothing is. Nor is it universally enjoyable; in fact, some find high-dose DXM experiences terrifying. But I believe that people can only make good decisions, or learn from bad decisions, if information is available. So please, use your head!

William White

May 10, 1995

--- --- --- --- --- --- --- --- --- --- --- ---


Important Information Regarding

Drixoral Cough Liquid Caps™

Since this document was completed, Drixoral Cough Liquid Caps™, one of the most popular forms of DXM for recreational use, have disappeared from the market. The official stance of Schering-Plough (the manufacturer) is that they were simply not popular. I strongly suspect, however, that recreational use was a major factor, if not the only factor, in their decision to pull the product from the market.

Replacing this product is a similar product (Drixoral Cough and Fever, if I remember correctly), which contains acetaminophen. Recreational use of any product containing acetaminophen could easily kill you.

As of this update, the Drixoral Cough Liquid Caps™ are still available in a few stores which have not sold or destroyed their stock. Another brand may come out with a similar product (or it may not; I don't know). If you wish to continue using DXM, I strongly suggest you switch to the extraction processes listed in Section 7.1 and 7.2. These processes will allow you to remove the DXM from cough syrups, using easily available materials, and yielding a pure product. Furthermore, since the DXM formed is the free base, rather than the hydrobromide salt, you can avoid excessive bromide intake (a potential problem with regular use of DXM - see Section 2.7).

If you choose to switch to, or continue using, cough syrups (e.g., Robitussin Maximum Strength Cough™ or Vicks Formula 44™), please be aware that the large amount of glucose, thickeners, etc., may be hard on your kidneys and pancreas. Precipitated DXM is probably safer.

I anticipate that DXM-only products will continue to disappear from the market, as more and more people learn of DXM's psychoactive potential. In response to this I am currently researching methods to extract DXM from DXM+guafenesin and DXM+acetaminophen products, giving high yield of pure DXM, and using easily available materials. I hope to complete these experiments by the end of the year (1995).


This page intentionally left blank


THE DEXTROMETHORPHAN FAQ

ANSWERS TO FREQUENTLY ASKED QUESTIONS

ABOUT DEXTROMETHORPHAN (DXM)



TABLE OF CONTENTS

                 
A Acknowledgements
 
1 Preliminary
1.1 Restrictions and Disclaimer
Distribution Restrictions
General Disclaimer
How to Reach the Author
1.2 Why a DXM FAQ?
1.3 Keeping DXM legal
1.4 How to Use This Document
 
2 General Information About DXM
2.1 DXM Quick Reference Page
2.2 What is Dextromethorphan Hydrobromide (DXM)?
2.3 What is Dextromethorphan Polistirex?
2.4 What is Dextrorphan (DXO)?
2.5 How does one obtain and use DXM?
Drinking Cough Syrup
Gelcaps and Capsules
Pharmaceutical and Chemical Suppliers
Extracted DXM Ingestion
Injection and Other Routes
2.6 What Are Some Typical DXM-containing Commercial Preparations?
1mg/ml DXM (120mg per 4oz bottle)
1.5mg/ml DXM (180mg per 4oz bottle)
2mg/ml DXM (240mg per 4oz bottle)
3mg/ml DXM (360mg per 4oz bottle)
15mg/capsule or tablet
30mg/capsule or tablet
2.7 What Should I Know About Other Drug Ingredients?
Decongestants
Antihistamines
Guaifenesin
Analgesics
Alcohol
Food Coloring / Dyes
Bromide Ions
Other "Inactive" Ingredients
2.8 Why Are So Many DXM Preparations in Liquid Form?
2.9 Is Recreational Use of DXM Illegal?
2.10 Other (Medical) Uses for DXM
2.11 Drug Interactions
2.12 What About Other Cough Suppressants?
2.13 Can DXM be Detected on Drug Tests?
 
3 The DXM Drug Experience
3.1 What is the General Character of a DXM Experience?
3.2 The First Plateau
Sensory Effects
Cognitive Effects
Motor Effects
Memory Effects
Emotional Effects
3.3 The Second Plateau
Sensory Effects
Cognitive Effects
Motor Effects
Memory Effects
Emotional Effects
3.4 The Third Plateau
Sensory Effects
Cognitive Effects
Motor Effects
Memory Effects
Emotional Effects
3.5 The Fourth Plateau
3.6 Is There Anything Beyond the Fourth Plateau?
3.7 What Happens with Long-term or Regular Use?
3.8 What are Some Fun or Interesting Things to Do on DXM?
Listen to Music
Dance
Go Swimming (low dose only!)
Group Tripping
Have Sex
Shamanic Journeying (see also Section 3.12).
Hang Out in a Sensory Deprivation Tank
3.9 What are Some Things to Avoid on DXM?
Heavy Exercise
Driving
Going to Class or School
Dose "Boosting" or Redosing
3.10 Why Does DXM Affect Different People so Differently?
3.11 How Does DXM Compare to Other Dissociatives?
3.12 Is There Any Connection Between DXM and Out-Of-Body or Shamanic Experiencies?
3.13 Why Can't I Hallucinate on DXM?
 
4 DXM Side Effects and Other Things to Avoid
4.1 What are the Potential Side Effects and Risks of Occasional Use?
Nausea and Other Gastric Disturbances
Itching and Allergic Reactions
Hangovers
Pupil Dilation
Tachycardia (increased heart rate)
Hot and cold flashes
Hyperthermia
Panic Attacks
Overexertion
Psychotic episodes
Hypertension
Miscellaneous
4.2 What are the Potential Side Effects and Risks of Regular Use?
Mania
Cognitive Impairment
Memory Impairment
Habituation and Psychological Addiction
Tolerance and Physical Addiction
Neurotoxicity
Excitotoxic Rebound
Psychosis
Kidney Damage
Bromide Poisoning
Miscellaneous
4.3 Is DXM Addictive?
4.4 Is DXM Withdrawal Dangerous?
4.5 DXM Hangovers -- Avoiding and Alleviating
4.6 How toxic is DXM? What is the LD50? Should I Worry?
4.7 Do You Recommend DXM for Recreational Use?
4.8 Help! What do I do if...?
Itching (the "Robo Itch")
Fast heartbeat and panic attacks
Irregular Heartbeat, or "Skipped Beats"
Nausea, Vomiting, Gas, and Diarrhea
Unconsciousness
High Body Temperature / Fever
Shortness of Breath
Sensation of Choking on One's Tongue
Nosebleeds
Feeling "Dead" / Losing One's Body
Hangovers (Lethargy and Feeling "Not All There"
Prolonged Dissociation from the Real World
 
5 Physiological Effects of DXM
5.1 How does DXM Inhibit the Cough Reflex?
5.2 How does DXM Cause its Psychoactive Effects?
General Information
Contribution of the PCP2 Binding Site
Contribution of the Sigma Binding Sites
Contribution of the NMDA Receptor
Contributions of Indirect Activity
Flanging
Hyper-Abstraction
Delusions and Memory Problems
5.3 Why does DXM Exhibit Plateaus?
Plateaus 1-3: Multiple Receptors
The Fourth Plateau
5.4 Why is This So Complicated?
5.5 How does DXM get Metabolized? (Pharmacokinetics)
Factors Affecting DXM's Metabolism
 
6 Neuropharmacology of DXM
6.1 What is a Receptor, Anyway? (Basic Neuropharmacology)
6.2 What are Sigma Receptors?
Sigma 1 Receptors and General Sigma Information
Sigma 2 Receptors
Sigma 3 Receptors
6.3 What are NMDA Receptors?
NMDA and Other Glutamate Receptors
NMDA Receptor Function and Structure
NMDA Receptors and Excitotoxicity
6.4 What are PCP2 Receptors?
6.5 What are Na+ and Ca2+ Channels?
6.6 How does DXM Compare to Other Drugs at These Receptors?
6.7 Endopsychosin and the Big Picture
 
7 DXM Chemistry and Extraction
7.1 How can I Extract DXM from Cough Formulae?
Acid-Base Extractions
Acid-Base Extraction of DXM
Precipitation Method
7.2 How can I Get Rid of Other Drug Ingredients?
7.3 How do I Use Free Base DXM?
7.4 How can I Synthesize DXM?
7.5 What can I Synthesize from DXM?
Dextrorphan
Levorphanol / Levomethorphan
3-substituted Analogs
 
8 Mixing DXM with Other Recreational Drugs
8.1 Alcohol
8.2 Barbiturates and Benzodiazepines
8.3 Amphetamines and Other Psychostimulants
8.4 Cannabis (Marijuana)
8.5 LSD, Psilocybin, and Other 5HT Hallucinogens
8.6 Opiates
8.7 PCP and Ketamine
8.8 Nicotine
8.9 Nootropics (Smart Drugs)
8.10 Miscellaneous Other Drugs
 
9 DXM Drug Culture
9.1 Is There, or Was There, a DXM Drug Culture?
9.2 Why Haven't I Ever Heard About It?
9.3 Is There a "Drug Slang" for DXM?
9.4 Are There any Street Names for DXM?
9.5 How do I Explain to My Friends that I'm Getting High Off Cough Syrup?
 
10 DXM Experiences and Personal Reports
10.1 First and Second Plateau Experiences
Positive Experiences
Negative Experiences
10.2 Third and Fourth Plateau Experiences
Positive Experiences
Negative Experiences
10.3 Long-term Use Experiences
Positive Experiences
Negative Experiences
10.3 Multiple Drug Experiences
DXM + Cannabis + Alcohol + Opium
DXM + Cyclizine
DXM + Psilocybe Mushrooms + LSD + Cannabis + Nitrous Oxide
 
Appendices
Appendix 1: P450 Inhibiting Drugs
Appendix 2: Receptor Binding of Recreational Drugs
Appendix 3: Other Sigma and NMDA Ligands
 
References
 
Glossary
 
Index

--- --- --- --- --- --- --- --- --- --- --- ---


Next Section   Index